Does Levodopa Harm Parkinson’s Patients When Used as Early Therapy?

Some studies have shown increased motor fluctuations in patients treated early in their course with levodopa. One strategy is to use medication such as Azilect and dopamine agonists until symptoms worsen. A new study concludes that this reasoning is faulty. Mobility in patients receiving initial levodopa over many years was equal to or even better than the mobility in other groups. This argues against avoiding levodopa, particularly in the treatment of older Parkinson’s patients. See Lancet Neurology, Volume 14, January 2015, page 10.

Jack Florin, MD

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